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肺癌是全球范围内最常见的癌症类型,其中非小细胞肺癌(NSCLC)占所有肺癌的80%,其最常见的突变为EGFR基因改变,EGFR是一种受体酪氨酸激酶,EGFR外显子20插入突变是NSCLC的一个独特亚群,此类患者通常对GFR受体酪氨酸激酶抑制剂治疗不敏感,且预后较差,目前尚无针对性的靶向疗法。