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去势抵抗性前列腺癌是指经去势治疗后病变复发或持续进展的前列腺癌,此类患者更容易出现转移,生存期较短,患者肿瘤细胞通常表达有前列腺特异性膜抗原(PSMA),PSMA以750个氨基酸糖蛋白的形式表达,而PSMA表达可能与肿瘤负荷相关,并可作为转移受累的指标。