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奥西替尼(osimertinib)是一种口服的,有效的,不可逆的egfr-tki,抑制egfr敏感突变和t790m抗性突变的激酶活性。对于egfrt790m阳性的非小细胞肺癌,应用奥希替尼(osimertinib)二线医治,有效概率为61%,pfs为9.6个月。