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KRAS是癌症中最常见的致癌基因,发生在近五分之一的肺癌中(大多为非小细胞型肺癌),KRAS与NRAS和HRAS有很高的同源性,AMG 510(索托拉西布)能抑制KRAS活性的药物也可能会抑制NRAS、HRAS的活性。AMG510的出现,给KRAS基因突变患者带来了福音!