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首个针对KRAS G12C突变的AMG 510(索托拉西布)利用蛋白表面隐藏的凹槽与之结合,将KRAS蛋白锁定在一种非激活的GDP结合状态,从而特异性、不可逆地抑制携带G12C突变的KRAS蛋白的活性。